characterize the relationship between
diet, microbiota and host phenotype

identify complex, non-linear relationships
between components of a biological system

challenge

a partner asked COSBI to investigate the effect of breastfeeding and formula feeding on infant microbiome

solution

by applying a network-based systems biology approach via enrichment of microbial species with host genes we determined the relationship between microbiota and host under different feeding conditions

outcome

a biological interpretation of the results led us to uncover that there is co-expression of more genes in breast-fed samples but lower microbial diversity compared to formula-fed

publications

G. Tini, L. Marchetti, M.-P. Scott-Boyer, C. Priami. Multi-omics integration – a comparison of unsupervised clustering methodologies. Briefings in Bioinformatics, doi: 10.1093/bib/bbx167, 2017.

S. Lacroix , J.K. Badoux , M-P. Scott-Boyer, S. Parolo , A. Matone , C. Priami , M. Morine , J. Kaput. A computationally driven analysis of the polyphenol-protein interactome. Nat. Sci. Rep., 8(2):2232, 2018.

M.G. Mathias, C. de Almeida Coelho-Landell, M.-P. Scott-Boyer, S. Lacroix, M.J. Morine, ..., C. Priami, J. Kaput, J. Pontes Monteiro. Clinical & vitamin response to a short-term multi-micronutrient intervention in Brazilian children & teens: from population data to inter-individual responses. Molecular Nutrition & Food Research, 1700613, 2018, doi:10.1002/mnfr.201700613.

C. Priami and M.J. Morine. analysis of biological systems. Imperial College Press, 2015

P. Praveen, F. Jordan, C. Priami, M.J. Morine. The role of breastfee- ding in infant immune system: a systems perspective on the intestinal microbiome. Microbiome, 3:41, 2015.

F. Jordan, M. Lauria, M. Scotti, T.-P. Nguyen, P. Praveen, M.J. Morine, C. Priami. Diversity of key players in the microbial ecosystems of the human body. Nat. Sci. Rep., 5:15920, 2015.

M.J. Morine, J. Pontes Monteiro, C. Wise, C Teitel, L. Pence, A. Williams, B. Ning, B. McCabe-Sellers, C. Champagne, J. Turner, B. Shelby, M. Bogle, R.D. Beger, C Priami, J. Kaput and the Phillips County Community Partners. Genetic associations with micronutrient levels identified in immune and gastrointestinal networks, Gene and Nutrition, 9:408, 2014.